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doi: 10.1093/oxfordjournals.alcalc.a044819

In a randomized, placebo-controlled intervention study with more than 900 older participants experiencing psychological distress, daily supplementation with folic acid (400 g) and vitamin B 12 (100 g) for two years did not reduce the occurrence of symptoms of depression despite significantly improving blood folate, vitamin B 12 , and homocysteine levels compared to placebo (109)

Won HR, Kang SU, Kim HJ, Jang JY, Shin YS, Kim CH

Who Should Be Cautious or Talk to a Clinician First While B12 supplementation at standard doses is safe for most people, certain situations call for extra care and professional guidance

(4) Prasad S, Tyagi AK, Aggarwal BB

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