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SCFAs receptors belong to the family of G protein-coupled receptors (GPCRs), including GPR41 and GPR43, which are important regulatory receptors for glucose metabolism and lipid metabolism, and can be activated by SCFAs to perform important physiological functions

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However, a variety of other risk factors have also been implicated in the development of malnutrition in people with obesity including defective storage and bioavailability of nutrients, small intestine bacterial overgrowth, low grade chronic inflammation (leading to oxidative stress and increased anti-oxidant utilization), older age and excessive consumption of simple sugars, milk and fat

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