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In summary, engineered extracellular vesicles, through precise functional design, show significant advantages in improving targeting, optimizing drug loading, and enhancing therapeutic effects, providing new technological pathways for the treatment of intervertebral disc degeneration

Simultaneously, the surface of Au-NPs can be modified with a Ausulfur (AuS) bond via chemical grafting or electrostatic coating, which endows nanomaterials with multiple biological functions (Pandey et al., 2019)

Bioavailability of oral formulations is typically 1-3% compared to near 100% for subcutaneous injection

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Davenne T, Percier P, Larbanoix L, Moser M, Leo O, Meylan E, et al