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While generally considered safe, semaglutide may be less effective for patients with MASH who dont also have obesity or diabetes, poses specific risks for older adults (like muscle loss and side effects), and isnt approved for children or teens or for those navigating severe complications like cirrhosis

Ketones become more likely when the smell is fruity and there is nausea, vomiting, abdominal pain, or rapid breathing

The FDA includes a boxed warning for thyroid C-cell tumors based on animal studies, though no human cases have been confirmed

These results drove enormous interest in tirzepatide and reshaped how clinicians think about peptides for weight loss as a category

For some substances, the monitoring timeline may be a few months, while for others it can last much longer

Lancet 2 (8571), 13001304