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doi: 10.1289/ehp.7417

There, Nrf2 binds to antioxidant response elements (ARE) located in the promoter regions of target genes, initiating the transcription of cytoprotective genes and subsequently upregulating the expression of HO-1 and superoxide dismutase 1 (SOD1)

Triggered by pH, enzymatic activity, or reductive environments, the payload is released at the desired location, improving drug selectivity and bioavailability

Differentiating effects of somatomedin-C/insulin-like growth factor I and insulin on Leydig and Sertoli cell functions
Muhammad W, Zhu J, Zhai Z et al (2022) ROS-responsive polymer nanoparticles with enhanced loading of dexamethasone effectively modulate the lung injury microenvironment
2007, 292 (3): H1398-H1403
