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Key results were repeated at a lower dose of 0.24 nmol kg 1 , comparable to that of exenatide when used clinically in humans after allometric scaling (Supplementary Fig

Consistent with CD-1 mouse PK data, intact AMG 133 has a shorter mean t 1/2,z compared to total AMG 133 (207 h versus 292 h)

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[DOI] [PubMed] [Google Scholar] 230.Blumer I, Pettus JH, Santos CT

Regulatory environment (external): Active uncertainty - FDA's April 2026 proposal to restrict 503B compounding remains open for public comment through June 29, 2026