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Animal studies show real gut-local efficacy orally

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The iterative stepwise modifications of the parent ligand Ang IV is first presented

The study was conducted on 32 male mice divided into four groups: a control (C) group receiving a standard diet with biotin, a biotin-deficient (BD) group on a biotin-free diet, a ketogenic control (KC) group on a ketogenic diet (low-carbohydrate and high-fat) with biotin, and a ketogenic biotin-deficient (KBD) group on a ketogenic diet without biotin

Dole NS, Mazur CM, Acevedo C, Lopez JP, Monteiro DA, Fowler TW, et al