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Hypoglycemia, injection site reactions, hypersensitivity reactions, and pancreatitis occurred as well, but these were much less common across trials

When cortisol stays elevated, it can interfere with the SCFA-driven signals and the circadian timing that normally support healthy GLP-1 activity, which may leave appetite harder to regulate

These metabolites benefit host health and cross-feed other commensal microbes, such as butyrate producers

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These improvements can lead to better emotional well-being, though individual results can vary.

The reason for this precaution is a) the lack of data on KD use in MCAD-deficient patients, and b) the fact that these patients respond well to glucose-based metabolism