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After 12 weeks treatment, the reductions in HbA1c from baseline were 0.96% with 1.8mg MAR709, 0.9% with 1mg tirzepatide and 1.7% with 5mg tirzepatide

There is no one-size-fits-all answer, and that is exactly why guidance matters.

Additionally, during covariate selection, age significantly affected the Emax value (Equation (7)) (Supplementary Fig

Not every patient needs this, but for patients with significant muscle mass concerns older adults, perimenopausal women, patients losing weight quickly at high doses it is worth considering

More if you are physically active, in hot weather, or have a higher body weight

Sarcopenia in mid-life predicts worse outcomes from any future illness, surgery, or fall
