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In a real-world cohort study of 18,386 propensity-matched patients on tirzepatide or semaglutide, more than half discontinued the drug within a year

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suggested that liraglutide improved serum lipid profile and hepatic steatosis by inducing autophagy through the adenosine monophosphate activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR) pathway [11], which has a key role in autophagy modulation [34]

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Meal size and timing: Eating smaller, more frequent meals rather than two or three large meals reduces the GI discomfort that GLP-1 agonists can cause