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A new post hoc analysis from the ADJUST-T1D trial looked at adults with type 1 diabetes and obesity using automated insulin delivery systems

As presented at the American Diabetes Association Meeting: this randomized phase 2b trial in 230 adults with overweight or obesity shows that aleniglipron, an oral small-molecule GLP1-RA, led to up to 11.3% body-weight loss compared with placebo after 36 weeks of treatment.

Many people wonder if they'll need to stay on semaglutide indefinitely to keep weight off

Beyond...

Strengths Acts via multiple pathways (GLP-1, AMPK, microbiome) Has existing human data showing reductions in fasting glucose, HbA1c, lipids Support receptor expression and islet health Limitations Low absorption and bioavailability Gastrointestinal discomfort is common (diarrhea, cramping)

Semaglutide has gained significant popularity in recent years due to its ability to promote weight loss