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[11] A systematic review and meta-analysis found that, using randomized controlled trials, that semaglutide is efficacious for sustained weight loss in patients with overweight/obesity and without diabetes

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According to the company's terms, Yucca Health itself is not a healthcare provider

Patients should report persistent stool changes to their GP, particularly if accompanied by abdominal pain, as GLP-1 therapy carries rare risks of pancreatitis and gallbladder disease

In line with this, the gastric emptying delay induced by GLP-1RAs is dependent on the presence of GLP-1Rs on these vagal afferents (Imeryuz et al., 1997)

Some patients continue treatment longer for weight maintenance, while others taper off once healthy habits are established