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Our data similarly revealed that DSF alone, especially at low concentration, had negligible effect on the activation of cGAS-STING pathway, while a combination treatment of DSF and Cu (II) at extremely low dose significantly and consistently triggered this pathway across multiple cancer cell lines, highlighting the critical role of Cu addition in activating innate immunity

Classically activated M1 macrophages, associated with pro-inflammatory functions, are often elevated in colonic tissues, releasing inflammatory mediators that exacerbate the inflammatory environment

doi: 10.1016/j.bbi.2015.09.013 504 TanakaSKuratsuneHHidakaYHakariyaYTatsumiK-ITakanoTet al

In this review, we summarize the structure, regulation, function, targeted drug development, and current research on CD38 in the cardiac context

Nevertheless, the question arises whether the loss of a circular cellular shape has metabolic implications by itself

Critical role for microglial NADPH oxidase in rotenone-induced degeneration of dopaminergic neurons
