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[DOI] [PMC free article] [PubMed] [Google Scholar] 125.Scirica B.M., Bhatt D.L., Braunwald E., Steg P.G., Davidson J., Hirshberg B

Phase 3 trial data has now demonstrated weight loss outcomes that, in some patient groups, approach those previously only achieved through bariatric surgery

Initially approved for type 2 diabetes management, recent studies highlight their potential in weight management and improving heart health in obese individuals

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It cannot be marketed for non-approved uses

Evidence Rating Level: 1 (Excellent) Study Rundown: Two prior phase three randomized controlled trials showed the efficacy and safety of once-weekly insulin icodec as compared to once-daily insulin glargine in adults with insulin-nave T2D