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Compared with the CSE+C646 group, the relative expression of p300, H4K12 and CyclinD1 protein after CTPB intervention increased, while TERT and Ki67 protein had no obvious change, which indicated that CTPB could partly affect the relative expression of p300, H4K12, CyclinD1, TERT and Ki67 protein in EPCs

Hence, it seems reasonable that UDCA was found to be associated with suppressor of HCC, because UDCA can ameliorate insulin sensitivity and liver inflammation by stabilizing the p53/MDM2 interaction and enhancing MDM2-dependent ubiquitination of p53 138

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p53 efficiently suppresses tumor development in the complete absence of its cell-cycle inhibitory and proapoptotic effectors p21, Puma, and Noxa

Rapuri PB, Gallagher JC, Balhorn KE, Ryschon KL

Vaping and mental health are closely linked , with people who vape having higher rates of anxiety and depression than non-users