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These toxicities can affect nearly any organ system but most commonly manifest as dermatologic toxicity, endocrinopathies, and severe autoimmune colitis , which requires prompt recognition and management with systemic corticosteroids

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Once the body exposed to oxidative stress, these GSH are doubled and make GSSG, which are oxidized states

This issue is of particular interest because simple in vitro experiments have shown that GSH can rapidly reduce DHA, even in the absence of an enzyme (Fig