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Key studies include Finis et al

2007;293:F1157F1165

however, a few problems still remain to be solved

Progress toward acetate supplementation therapy for Canavan disease: glyceryl triacetate administration increases acetate, but not N-acetylaspartate, levels in brain

Compounds that activate PGC-1an essential regulator of mitochondrial biogenesis and oxidative metabolismhave demonstrated promise in recovering mitochondrial function and increasing mitochondrial content [112]

10.1021/acs.jmedchem.0c01016 31 HwangJ.NguyenL
