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Required for doses that require 50-100 units

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The innovators proprietary cell line and exact upstream and downstream processing parameters are trade secrets, meaning a biosimilar manufacturer cannot replicate the process

Such ratio significantly increased from baseline after 26 weeks of treatment with liraglutide 1.8 mg/day, indicating a reduction in liver steatosis, whereas it was unchanged in patients treated with lower doses of liraglutide, glimepiride or placebo

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