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( e ) Representative 2D-classes from negative-stain, single-particle electron microscopy of GLP-1R/Ex4-D-Ala/DNGas/G1/G2/Nb35 complex

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Acknowledgments We thank Helen Lilley (Mtech Access) who provided medical writing services in the preparation of the manuscript, funded by consultancy payments from Novo Nordisk

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Some contributing factors include: Rapid fat loss around the jawline, chin, and neck Loss of skin elasticity with age Pre-existing volume loss that becomes more visible after weight loss Genetic predisposition to looser neck skin or a weaker chin/jawline structure While the aesthetic results of weight loss are often positive, many patients find that their new slimmer silhouette comes with unexpected signs of agingespecially in delicate areas like the neck