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The study showed that PR-104A induced extensive inter-strand DNA cross-links under hypoxic conditions, with cytotoxic potency correlating strongly with the extent of hypoxia and enzymatic reduction, particularly via aldo-keto reductase 1C3 in normoxic settings

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Bone Marrow : The bone marrow is the principal site of lymphocyte production, particularly for B cells
Activation/deactivation of acetylcholinesterase by H2O2: more evidence for oxidative stress in vitiligo
