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Hypertonic chyme is detected by duodenal osmoreceptors and gastric emptying is slowed [51, 52]
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In the same clinical trial, the incidence of constipation was 7% with 1 mg, 6-15% with 4 mg, 6-11% with 8 mg, and 16% with 12 mg dose of retatrutide compared to 3% in the placebo group
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The more time you spend without eating, the more time throughout the day that your body has to be burning fat to survive
