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Toxicon: official journal of the International Society on Toxinology 60, 596602, doi: 10.1016/j.toxicon.2012.05.027 (2012)

Understanding GLP-1 Medications and their Benefits GLP-1 receptor agonists are commonly used to treat type 2 diabetes and obesity

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GLP-1RAs and osteoclasts The greater degree of bone degradation observed in mice lacking GLP-1R indicates that GLP-1R signaling suppresses osteoclast differentiation and bone resorption

"Sagging skin due to loss of subcutaneous fat, collagen and muscle mass, injection site reactions, like a rash, redness or swelling where one injects the medications are also common." Spearman explains that age also plays a role because as we get older and our skin matures, the number of elastic and collagen fibers decreases

premixing into a minibag and infusing over 10-15 minutes is acceptable for larger cumulative doses and may reduce burning at injection sites