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Hormone replacement therapy and its relationship to lipid and glucose metabolism in diabetic and nondiabetic postmenopausal women: Results from the third national health and nutrition examination survey (NHANES III)

That changed in 2025 and 2026 with the FDA approval of two oral options: the Wegovy pill (oral semaglutide, approved December 2025) and Foundayo (orforglipron, approved April 2026)

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But the category has also become crowded and confusing

This guide breaks down what is happening biologically, which treatments address each concern, and why starting early matters more than most people realize