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10.3390/ph13090230 61 JensenJ

It has also been demonstrated that inhibitory GABAergic CNS GIPR + neurons are necessary for the food intake reducing effects of GIPR agonists and dual incretin co-agonists (54, 55), while excitatory glutamatergic CNS GLP-1R + neurons are necessary for the food intake reducing effects of GLP-1R agonists (71)

Hypothalamic AMP-activated protein kinase as a whole-body energy sensor and regulator

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All three ECLs and ICLs were well-resolved, whereas the stalk was disordered

Regarding the primary endpoint, all doses of tirzepatide were superior in comparison to semaglutide