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[25] [66] The US Food and Drug Administration (FDA) approved semaglutide based on evidence from seven clinical trials of 4087 participants with type 2 diabetes

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Conditions such as reflux, gastritis, or delayed gastric emptying can make symptoms worse

Figure 1 presents the main effects of GLP1, GIP and glucagon in different body organs

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gastrointestinal hormones released after nutrient intake with the ability to glucose-dependently augment insulin secretory responses during periods characterized by hyperglycemia) triggered the development of GLP-1 receptor agonists (GLP-1 RAs)
