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Based on SURMOUNT-1 data analysis, tirzepatide decreased the 10-year estimated risk of ASCVD for obese or overweight patients

Additional populations requiring careful consideration include patients with kidney disease (specific recommendations vary by medication), those with a history of diabetic retinopathy (particularly if rapidly improving glycemic control), and individuals with active or recent malignancy

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Dietary fiber and prebiotics and the gastrointestinal microbiota

Weight loss without diabetes GLP-1 medications have expanded beyond diabetes treatment entirely

an E-value above 2.0 was considered moderately robust, and above 3.0 strongly robust