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It has been observed that older monozygotic twin pairs demonstrate greater DNA methylation differences than younger monozygotic twin pairs ( epigenetic drift might be due to the accumulation of small errors in copying DNA methylation marks during successive cell divisions ( epigenetic drift ( TISSUE-SPECIFICITY OF DNA METHYLATION PATTERNS A considerable similarity in DNA methylation levels exists across different tissues

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Therefore, it Combined oral contraceptives may also Non-oral hormonal contraceptives, including birth control patches, vaginal rings, and injections, may have a similar risk to combined oral contraceptives