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Accelerated amyloid angiopathy and related vascular alterations in a mixed murine model of Alzheimers disease and type two diabetes

Identifying the compounds and pathways that stimulate endogenous GLP-1 secretion remains a critical step in advancing this therapeutic avenue

doi: 10.1056/NEJMoa1612917 16 GreenJBHernandezAFDAgostinoRBGrangerCBJanmohamedSJonesNPet al

10.1111/dom.12802 Summary Keywords type 2 diabetes, DPP-4 inhibitors, oral antidiabetic, incretin-based therapy, gliptin, combination therapy Citation Gallwitz B (2019) Clinical Use of DPP-4 Inhibitors

administration of the experimental compounds (MK-801, GLP-1, GLP-1MK-801 (all at doses of 100 nmol kg 1 ), semaglutide (10 nmol kg 1 ) or isotonic saline as vehicle)

It has several functions, including enhancing insulin secretion, reducing glucagon production, and slowing gastric emptying, which all synergistically work to reduce blood glucose levels