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Furthermore, clinical trials have shown that standard NRT doses are inadequate for rapid metabolizers of nicotine (i.e., those who inactivate nicotine to cotinine and then to 3-hydroxycotinine [3-HC] more quickly than others due to genetic variation affecting the activity of the hepatic enzyme CYP2A6) [20, 25]

take insulin or any prescription medications

You can select your preferred density among three options by pressing the left button beneath the display

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It works by reducing cravings for nicotine and blocking its effect on the brain, while also helping with withdrawal symptoms, such as feeling irritable or having difficulty sleeping

This rapid onset can create a surge of dopamine