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McKenzie, J (2018)

However, when used in amounts relevant to smokers, they were not seen to affect rat self-administration of nicotine (Smith et al., 2015) and no pharmacological effects have been reported from the known tobacco MAO inhibitors at physiologically relevant concentrations

John Middleton, the brain behind Black and Mild cigars, decided that pipe tobacco should be enjoyed by a larger population than the one willing to clean, tamp, and pack a pipe