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Involving tobacco companies in the regulation of their own products not only undermines public health but also violates the global standards for tobacco regulation laid out in the World Health Organization Framework Convention on Tobacco Control (FCTC) Article 5.3, which the U.S

1 g of linearized plasmid was used for in vitro transcription using the MEGAscript T7 Transcription Kit (Ambion) as per manufacturers protocol

can be attributed to their emergence as an alternative to traditional combustible tobacco products, particularly as a growing number of smokers sought ways to quit

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