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The nicotine patch is a wearable form of nicotine replacement therapy

[8] Thanks Ingesting far too much nicotine results in acute nicotine poisoning, which is characterized by stomach aches, difficulty breathing, confusion, vomiting, headache, and loss of consciousness

This is just an interesting side note, really, but it provides an interesting, entertaining commentary on the value of design and the importance of protecting intellectual property
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If the production of gas phase toxins increases less than the increase in TPM, then exposing the rats to a fixed amount of TPM will reduce exposure to the gaseous constituents