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Nicotine Replacement Treatments Nicotine replacement therapies (NRTs), such as nicotine gum and the transdermal nicotine patch, were the first pharmacological treatments approved by the Food and Drug Administration (FDA) for use in smoking cessation therapy

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[3] [4] Its name (along with that of the Winston brand) derives from Winston-Salem, North Carolina, the city where RJR was founded and headquartered