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Beyond the substance itself, individual factors include genetic predisposition (approximately 40 to 60 percent of addiction risk is heritable), age of first use (earlier onset dramatically increases risk), co-occurring mental health conditions, history of trauma, and the social and environmental context of use

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And remember while the set quantities are generally accepted, exceeding them could lead to unnecessary complications

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Consequently, it is difficult to make generalizations about efficacy for cessation based on clinical trials involving a particular e-cigarette, and there is presently inadequate evidence to conclude that e-cigarettes, in general, increase smoking cessation