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One possible explanation for these regions of relative deactivation may be the shift from ventral to dorsal striatum that occurs as drug use becomes habitual and compulsive 29 , and the finding that dysfunctional inhibitory mechanisms in the prefrontal cortex also play a role in addictive behaviour 29, 30

[DOI] [PMC free article] [PubMed] [Google Scholar] Jeffery RW, McGuire MT, French SA

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