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The long-held trope among party centrists is that Democrats lost the white working class over cultural issues: God, guns, and gays. Frank emphatically rejects this view, instead channeling his inner Elizabeth Warren and making the case that his partys problems with the white working class are almost wholly economic

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Autosomal dominant mutations in the COL1A1 or COL1A2 genes in OI patients disrupt the synthesis and structure of type I collagen, which in turn leads to Osteogenesis Imperfecta, also known as the brittle bone disease