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Third, the varenicline and placebo groups were not well-matched for anxiety and e-cigarette dependence levels

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53 However, because NRT has the potential to cause fetal harm and because of insufficient evidence supporting its efficacy in pregnant women, the 2008 clinical practice guideline does not recommend use during pregnancy

Nicotine acts to increase the production of other chemicals in the brain known as neurotransmitters that affect brain function

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