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These observations contradict previous findings, where no significant difference in cellularity was observed between two loading regimens, and where the immobilized group exhibited higher fiber organization, an elevated collagen type 1:3 ratio, and increased echogenicity compared to a group engaged in early treadmill running 12

This matrix provides cartilage with strength, flexibility and load-bearing capacity by creating a dense structural network around cartilage cells

After digestion by trypsin, half cells per samples were taken out followed by co-cultivation with uninfected cells which were labeled with CellTracker Blue fluorescence dye (MedChemexpress)

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(ii) per-orally, in drinking water (0.16 g/mL, 0.16 ng/mL, 12 mL/rat/day), till the sacrifice at 7, 14, 28 and 42 postoperative days

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