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found an association between obesity and KSD regarding gender, which shows the multivariable relative risk for stone formation in men with a BMI of 30 or greater compared with men with a BMI of 21 to 22.9 was 1.33 (95% CI 1.081.63), and the corresponding relative risks for the same categories of BMI in older and younger women were 1.90 (95% CI, 1.612.25) and 2.09 (95% CI, 1.772.48), respectively [36]

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However, studies in IQOS users observed a larger mean puff volume (around 6065 mL) and a shorter puff intervals (about 1012 s) compared to the HCI standardized regime (puff volume of 55 mL and puff interval of 30 s) 25,26,27

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