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These individual variations in nicotine tolerance are at least in part due to the pharmacogenetics of Cytochrome P450 2A6 (CYP2A6), the hepatic enzyme primarily responsible for nicotine metabolism [18]

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Additionally, immune system dysfunction, either due to underlying health conditions or external factors such as infections, might contribute to PR recurrence, though this area requires further study [14]

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Also known as beedies, the Bidi makers use Tendu Leaves to wrap the blend