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Retrieved November 23, 2016
This article discusses the FDAs regulatory approaches to smokeless tobacco harm reduction

In other words, its a full-blown nicotine addiction

Estimating the Volume of Contraband Sales of Tobacco in Canada: 2006-2010
Reynolds, a unit of Reynolds American Inc., could not be reached on Friday evening as their offices were closed

97 Nicotine is a potent inducer of epithelial-mesenchymal transition by inhibiting the expression of E-cadherin and -catenin and can induce and facilitate transcription of mesenchymal genes such as fibronectin and vimentin in many cell lines
