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Hegele RA, Ginsberg HN, Chapman MJ, Nordestgaard BG, Kuivenhoven JA, Averna M, et al

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5 adenosine monophosphate-activated protein kinase (AMPK) is an enzyme that controls key players of metabolic pathways, thus emerging as a major regulator of glucose and lipid metabolism through multiple beneficial roles in the target tissues, liver, adipose, and muscle (4)

To provide a more thorough theoretical foundation for treating disorders associated to TMAO, larger-scale clinical trials are needed to validate TMAOs potential as a biomarker for various diseases along the gut-organ axis