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A single-blind, randomized, crossover trial of the effects of a nicotine pouch on the relief of tobacco withdrawal symptoms and user satisfaction

doi: 10.1016/j.freeradbiomed.2018.01.011 22 da SilvaE

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Stuart King James I wrote a famous polemic titled A Counterblaste to Tobacco in 1604, in which the king denounced tobacco use as "[a] custome lothsome to the eye, hatefull to the Nose, harmefull to the braine, dangerous to the Lungs, and in the blacke stinking fume thereof, neerest resembling the horrible Stigian smoke of the pit that is bottomelesse ." [13] That year, an English statute was enacted that placed a heavy protective tariff on tobacco imports