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Physiologic and performance effects [of amphetamines] Amphetamines increase dopamine/norepinephrine release and inhibit their reuptake, leading to central nervous system (CNS) stimulation Amphetamines seem to enhance athletic performance in anaerobic conditions 39 40 Improved reaction time Increased muscle strength and delayed muscle fatigue Increased acceleration Increased alertness and attention to task "Smart drugs and synthetic androgens for cognitive and physical enhancement: revolving doors of cosmetic neurology"

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Higher levels of norepinephrine may help with focus and concentration in people with ADHD

However, in human studies, this approach has failed to provide clinically relevant benefit