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Phase 2 trials test a drug on a few hundred participants over a year or so to establish efficacy and identify side effects

The three arms of the mechanism each contribute a distinct effect: GLP-1 receptor agonism drives central appetite suppression and slowed gastric emptying

Key features of retatrutide include: Acts as a triple agonist on GLP-1, GIP, and glucagon

Practical considerations include cost and route of administration, as most formulations are injectable, although oral preparations are emerging

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Beavers KM, Neiberg RH, Johnson KC, Davis CH, Casanova R, Schwartz AV, et al