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it can be used any time and with a potentially higher frequency than combustible cigarettes

Over time, these sacs can break down so that a person with emphysema might struggle to get enough air, even when at rest

[40] [43] In 1991, the Federal Court found advertisements denying environmental smoke to be misleading

Nicotine exposure affected energy metabolism by unbalancing the TCA cycle and activating anaerobic respiration, leading to a significant drop in ATP concentration

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Chuang et al, Effects of neighborhood socioeconomic status and convenience store concentration on individual-level smoking, Journal of Epidemiology and Community Health , 59 (2009): 56873