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Pharmacokinetics of freebase nicotine and nicotine salts following subcutaneous administration in male rats

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Inclusion and exclusion criteria Included in this analysis were current cigarette smokers aged 20 years and older, defined as the survey participants who had smoked at least 100 cigarettes in their lifetime that captured established smoking behaviour as used by the centres for Disease Control and Prevention (CDC) 18 and had smoked cigarettes at least one time in the 5 days prior to the examination interview when blood was drawn for cotinine measurement (see figure 1)