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Reynolds Metals was a major metals and aluminum foil manufacturer that was focusing its research on using aluminum silicate and silicate fibers to filter and cool cigarette smoke

middle notes are Tobacco, Vanilla, Tonka Bean and Cacao

Pharmacol 74 , 111 (2016)

A generalised version of this model (other than step d) relates equally to the production of cigarette tobaccos, and therefore data for these tobaccos were included in the following discussion