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Description
Nicotine metabolism is important in reducing toxicity: cotinine has a similar mechanism of action to nicotine, but binds to neuronal acetylcholine receptors with lower potency 18

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Furthermore, CSE has adverse effects on mitochondrial integrity in RPE cells [29,30,31] as well as lung, airway, and bronchial epithelial cells [32,33,34,35,36]

Tobacco products produce a significant carbon footprint throughout the entire supply chain process
