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ISSN 0899-3289

In a study in which nonsmokers received an intravenous infusion of nicotine with and without pretreatment with high doses of cotinine, there was no effect of cotinine on the clearance of nicotine (Zevin et al

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"The Discovery of the Causal Agent of the Tobacco Mosaic Disease" (PDF)

This process was observed on a constant basis and the colonies flourished further after the Maryland and Carolina colonies were established and their plantations began to produce more tobacco

[13] The United States Department of Defense followed, raising the age to purchase tobacco to 21 on military bases in the U.S